| Safinamide MesylateMAO-B inhibitor,potent,selective and reversible |
Sample solution is provided at 25 µL, 10mM.
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- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
| Description | Safinamide Mesylate is a potent and selective inhibitor of MAO-B with IC50 value of 98 nM. | |||||
| Targets | MAO-B | |||||
| IC50 | 98 nM | |||||
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| Cas No. | 202825-46-5 | SDF | Download SDF |
| Synonyms | FCE-28073, PNU 151774E, methanesulfonate | ||
| Chemical Name | (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide;methanesulfonic acid | ||
| Canonical SMILES | CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F.CS(=O)(=O)O | ||
| Formula | C17H19FN2O2.CH4O3S | M.Wt | 398.45 |
| Solubility | ≥16.1 mg/mL in DMSO, ≥10.08 mg/mL in EtOH with ultrasonic and warming, ≥84.6 mg/mL in H2O | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Safinamide mesylate is the methanesulfonic acid form of its active component safinamide, a selective and reversible monoamine oxidase B (MAO-B) inhibitor with the value of 50% inhibition concentration IC50 of 98 nM. Having been used for the treatment of Parkinson’s disease (PD), safinamide potently modulates dopamine (DA), a substrate of MAO-B, suppressing DA uptake and reversibly binds to MAO-B blocking the function of MAO-B, which lead to the relief of PD symptoms. Besides MAO-B inhibition, safinamide exhibits novel anticonvulsant activities, including sodium channel blockade, calcium channel blockade and glutamate release inhibition, with values of IC50 of 8.2 μM, 31.5 μM and >56.4 μM respectively.
Reference
Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P, Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M, Salvati P, Post C. Preclinical evaluation of PNU-151774E as a novel anticonvulsant. J Pharmacol Exp Ther. 1998; 285(2): 397-403
Onofrj M, Bonanni L, Thomas A. An expert opinion on safinamide in Parkinson"s disease. Expert Opin Investig Drugs. 2008;17(7):1115-1125
Naveed M Malek, Donald G Grosset. Investigational agents in the treatment of Parkinson"s disease: focus on safinamide. Journal of Experimental Pharmacology 2012: 4 85-90
