ApexBio/发现探针™ 血管生成相关化合物面板/5mg/well/L1001
市场价：
¥17500.00
美元价：
8750.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Related Products
- ML161
- IOX2(Glycine)
- DMXAA (Vadimezan)
- AVL-292
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Molarity CalculatorDilution Calculator
| DiscoveryProbe™ Angiogenesis-related Compounds Panel |
Sample solution is provided at 25 µL, 10mM.
Click and Customize the Panelwith your own choices of compounds/size/quantities/chemical forms etc.
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| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A3206 | AVL-292 | Btk inhibitor, selective and oral | Angiogenesis|BTK | 1202757-89-8 | COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F | |
| A4189 | IOX2(Glycine) | Poten HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor | Angiogenesis|HIF | 931398-72-0 | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O | |
| A8660 | Cilengitide | Integrin inhibitor for αvβ3 and αvβ5 | Angiogenesis|Integrin | 188968-51-6 | CC(C)C1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N | |
| A8229 | ML161 | PAR1 inhibitor | Angiogenesis|PAR1 | 423735-93-7 | CCCC(=O)NC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2Br | |
| A8233 | DMXAA (Vadimezan) | Tumnor vascular disrupting agent, apoptosis inducer | Angiogenesis|VDA | 117570-53-3 | CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C | |
| Download the Angiogenesis related Compounds Panel - XLSXDownload the Angiogenesis related Compounds Panel - SDF | ||||||
Related Biological Data
In the Burkitt lymphoma cell line Namalwa, the anti-IgM–induced phosphorylation of protein kinase B (PKB/AKT) and ERK were inhibited by PCI-32765 , whereas phosphorylation of the activating LYN/SYK substrate site Y551 of BTK was actually upregulated.
Review (University of Minnesota)
Fura-2 loaded purified basophils were incubated with vehicle control (0.0005% DMSO) or 50 nM PCI-32765 for 10 minutes prior to the addition of 0.5 μg/ml anti-IgE antibody and the cytosolic calcium response monitored. The 350/380 excitation ratio is plotted for the average of two experiments.
Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
" to show IC50- Available in stock with overnight delivery and free shipping over $500
- Cost-effective and competitive price to save your findings
- Potent, selective and cell-permeable in inhibiting or activating target molecules
- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
- Detailed files describing potency, selectivity and applications etc.
- Supported by published data from top peer-reviewed journals
- Guaranteed high quality with NMR and HPLC validation
| Solubility | Soluble in DMSO | Storage | Desiccate at -20°C |
| Packaging | 96 well plate | Form | Powder |
| General tips | For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request | ||
A wide range of well-characterized bioactive molecules that covers various targets related to angiogenesis, including Btk, integrin and HIF-1 etc. Facilitate your research towards the insights of tumorigenesis, cardiovascular disease and wound repair etc. Applicable in cellular assays, animal models and drug screenings etc.
1. Sakurai T, Kudo M. Signaling pathways governing tumor angiogenesis. Oncology. 2011;81 Suppl 1:24-9.Abstract We highlight the regulation of angiogenesis and discuss the potential of molecular targeting as a new therapeutic approach to tumor angiogenesis. Tumor angiogenesis is connected with many signaling pathway. Such as vascular endothelial growth factor (VEGF), fibroblast growth factor etdl, both of them were proangiogenic factors, and those antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin.
2. Sali TM, Pryke KM, Abraham J et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324.Abstract The chemically unrelated 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a synthetic small molecules, is capable of activating the STING pathway which exhibits other immunotherapeutic effects including anti-angiogenic vascular disruption promoting tumor necrosis. We explored patterns of DMXAA-stimulated innate immune activation in murine cells to evaluate their resemblance with those induced by G10 in human cells. Recults illustrates that DMXAA-induced IRF3 phosphorylation in RAW264.7 macrophage-like cells is detectable by 1h post-treatment. Furthermore, DMXAA also elicits dose-dependent transcription of key innate antiviral genes IFNβ, ISG15, IFIT2, and Viperin in a manner similar to that observed for G10 in human cells.
品牌介绍
APExBIO（APExBIO Technology LLC）总部位于美国休斯顿，是一家自主研发生产、致力于为生命科学研究提供高性能产品和优质服务的供应商。公司现阶段涵盖丰富的产品线，主要包括：1. 10000 多种小分子抑制剂/激动剂——用于肿瘤、免疫、神经等生物医药各研究领域。2. 40 余个高通量化合物库——药物筛选最佳工具。3. 分子生物学产品——PCR、逆转录、qPCR、克隆、高通量 DNA 文库构建等试剂和试剂盒，公司对相关酶进行改造，使其稳定性、催化活性等有极大的提升。4. 体外转录——公司拥有国内独家mRNA体外转录合成平台，提供优质的修饰核苷酸、转录酶等各种合成原料，并可提供mRNA订制服务。5. Cy 染料、生物素——高纯度、种类丰富的 Cy 染料和生物素可用于蛋白检测、纯化等研究。6. 免疫学产品——各类细胞器染料及靶标信号放大的链霉亲和素系列和TSA系列。7. 试剂盒——高性能的 MTT、CCK-8、EdU 细胞增殖与毒性检测 Kit 和 Annexin V、Caspase 凋亡检测 Kit。8. 蛋白研究——蛋白提取抑制剂 cocktail、磷酸化蛋白研究新工具 phosbind。9. 组学服务——提供微生物多样性、转录组学等高通量测序服务。
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