ApexBio/发现探针™ DNA损伤/DNA修复相关化合物面板/5mg/井/L1007
市场价：
¥102200.00
美元价：
51100.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Related Products
- VE-822
- KU 55933
- Rocilinostat (ACY-1215)
- SCR7
- (S)-Crizotinib
- JNJ-26481585
Molarity CalculatorDilution Calculator
| DiscoveryProbe™ DNA Damage/DNA Repair-related Compounds Panel |
Sample solution is provided at 25 µL, 10mM.
Click and Customize the Panelwith your own choices of compounds/size/quantities/chemical forms etc.
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| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A4605 | KU 55933 | ATM inhibitor,potent and selective | DNA Damage/DNA Repair|ATM/ATR | 587871-26-9 | C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4 | |
| B1383 | VE-822 | ATR inhibitor | DNA Damage/DNA Repair|ATM/ATR | 1232416-25-9 | CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N | |
| A8705 | SCR7 | DNA ligase IV inhibitor | DNA Damage/DNA Repair|DNA Ligases | 1533426-72-0 | S=C(NC(/N=C/C1=CC=CC=C1)=C2/N=C/C3=CC=CC=C3)NC2=O | |
| A4083 | Rocilinostat (ACY-1215) | Selective HDAC6 inhibitor | DNA Damage/DNA Repair|HDAC | 1316214-52-4 | C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO | |
| A4090 | JNJ-26481585 | Potent HDAC inhibitor | DNA Damage/DNA Repair|HDAC | 875320-29-9 | CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO | |
| A8802 | (S)-Crizotinib | Potent MTH1 inhibitor | DNA Damage/DNA Repair|MTH1 | CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N | ||
| A1945 | BIBR 1532 | Telomerase inhibitor,novel and selective | DNA Damage/DNA Repair|Telomerase | 321674-73-1 | CC(=CC(=O)NC1=CC=CC=C1C(=O)O)C2=CC3=CC=CC=C3C=C2 | |
| A3966 | Doxorubicin | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | DNA Damage/DNA Repair|Topoisomerase | 23214-92-8 | CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O | |
| Download the DNA Damage/DNA Repair-related Compounds Panel - XLSXDownload the DNA Damage/DNA Repair-related Compounds Panel - SDF | ||||||
Related Biological Data
RPE cells were treated with TSA at various concentrations (0.2, 0.4, 0.8 and 1.0 μM). The protein expression levels of cyclinD1, CDK4 and CDK6, p-Rb, P21 and P27 were detected by western blot.
Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
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- Potent, selective and cell-permeable in inhibiting or activating target molecules
- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
- Detailed files describing potency, selectivity and applications etc.
- Supported by published data from top peer-reviewed journals
- Guaranteed high quality with NMR and HPLC validation
| Solubility | Soluble in DMSO | Storage | Desiccate at -20°C |
| Packaging | 96 well plate | Form | Powder |
| General tips | For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request | ||
A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc. Applicable in cellular assays, animal models and drug screenings etc.
1. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature. 2012 Jan 18;481(7381):287-94.Abstract Genomic instability is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.
2. Park J, Thomas S, Munster PN. Epigenetic modulation with histone deacetylaseinhibitors in combination with immunotherapy. Epigenomics. 2015;7(4):641-52.Abstract HDAC inhibitors have been approved as single agents for cutaneous and peripheral T-cell lymphoma and have shown promising activity in reversing therapy resistance in other tumor types. This review describes the current understanding on integrating HDAC inhibitors into various immunotherapeutic approaches, such as cancer vaccines, adoptive T-cell transfer and immune checkpoint inhibitors. Furthermore, it summarizes promising treatment strategies in epigenetic immune priming from clinical trials that are currently underway.
品牌介绍
APExBIO（APExBIO Technology LLC）总部位于美国休斯顿，是一家自主研发生产、致力于为生命科学研究提供高性能产品和优质服务的供应商。公司现阶段涵盖丰富的产品线，主要包括：1. 10000 多种小分子抑制剂/激动剂——用于肿瘤、免疫、神经等生物医药各研究领域。2. 40 余个高通量化合物库——药物筛选最佳工具。3. 分子生物学产品——PCR、逆转录、qPCR、克隆、高通量 DNA 文库构建等试剂和试剂盒，公司对相关酶进行改造，使其稳定性、催化活性等有极大的提升。4. 体外转录——公司拥有国内独家mRNA体外转录合成平台，提供优质的修饰核苷酸、转录酶等各种合成原料，并可提供mRNA订制服务。5. Cy 染料、生物素——高纯度、种类丰富的 Cy 染料和生物素可用于蛋白检测、纯化等研究。6. 免疫学产品——各类细胞器染料及靶标信号放大的链霉亲和素系列和TSA系列。7. 试剂盒——高性能的 MTT、CCK-8、EdU 细胞增殖与毒性检测 Kit 和 Annexin V、Caspase 凋亡检测 Kit。8. 蛋白研究——蛋白提取抑制剂 cocktail、磷酸化蛋白研究新工具 phosbind。9. 组学服务——提供微生物多样性、转录组学等高通量测序服务。
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