ApexBio/发现探针™ 内分泌和激素相关化合物小组/5mg/well/L1008
市场价：
¥39800.00
美元价：
19900.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
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| DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel |
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| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A2150 | Andarine | Selective androgen receptor agonist | Endocrinology and Hormones|Androgen Receptor | 401900-40-1 | C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O | |
| B1534 | AZD1981 | CRTh2 antagonist,potent and selective | Endocrinology and Hormones|CRTH2 | 802904-66-1 | CC1=C(C2=C(N1CC(=O)O)C=CC=C2NC(=O)C)SC3=CC=C(C=C3)Cl | |
| A1428 | Fulvestrant | Estrogen receptor antagonist,high affinity | Endocrinology and Hormones|Estrogen/progestogen Receptor | 129453-61-8 | CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F | |
| B1518 | Erteberel (LY500307) | Erβ agonist, potent and selective | Endocrinology and Hormones|Estrogen/progestogen Receptor | 533884-09-2 | C1CC2C(C1)C3=C(C=CC(=C3)O)OC2C4=CC=C(C=C4)O | |
| B3238 | XCT790 | ERRα agonist | Endocrinology and Hormones|Estrogen/progestogen Receptor | 725247-18-7 | COC1=C(C=CC(=C1)C=C(C#N)C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F | |
| A2986 | ADL5859 HCl | δ-opioid receptor agonist,selective | Endocrinology and Hormones|Opioid Receptor | 850173-95-4 | CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C(=CC=C4)O.Cl | A8456 | JTC-801 | KOR-3 (NOP) receptor antagonist, high affinity and selective | Endocrinology and Hormones|Opioid Receptor | 244218-51-7 | CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C=C4N)C.Cl | A8019 | Perindopril Erbumine | Potent angiotensin-converting enzyme (ACE) inhibitor | Endocrinology and Hormones|RAAS | 107133-36-8 | CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N |
| Download the Endocrinology and Hormones-related Compounds Panel - XLSXDownload the Endocrinology and Hormones-related Compounds Panel - SDF | ||||||
Related Biological Data
KLK3 (top) and NKX3-1(bottom) expression which were the AR target genes in various resistant clones were analyzed by QPCR.All lines were pretreated with vehicle (−) or doxycycline (+) for 3 days before treatment with DMSO (left) or 10 μmol/L MDV3100 (right) for 24 hours in 10% FCS. TBP was used to normalize expression. Data represent mean ± SEM; n = 3. *, P < 0.05;="" **,="" p="">< 0.01="" (student="" t="" test).="" the="" f876l="" mutation="" is="" sufficient="" to="" induce="" genetic="" and="" phenotypic="" resistance="" to="" mdv3100.="">
Review (Georgia Regents University)
Comparison of different anti-androgen/AR compounds on TGF-β1/Smad3/MMP9 signaling in PCa cells. CWR22Rv1 cells treated with 10 μM CASO, 10 μM MDV, 10 μM ASC, 5 μM CTS, or vehicle for 3 days were harvested. The expressions of TGF-β1, p-Smad3, Smad3, MMP9, and GAPDH were analyzed by Western blot analysis. All of the experiments have been repeated twice independently. *, p< 0.05;="" **,="" p="">< 0.01;="" ***,="" p="">< 0.001.="" error="" bars,="" s.d.="" casodex="" and="" mdv3100="" enhanced="" tgf-beta,="" mmp9="" expression="" in="" cwr22rv1="" cells.="" whereas="" asc-j9="" and="" cts="" treatment="" did="" not.="">
Review (University of Glasgow )
Chronic exposure to ENZA resulted in autophagy. To mimic resistant to ENZA, C4-2B cells were subjected to 20 μM ENZA over a period of 3 months and selected for a sub-population of resistance cells (C4-2B+R). Upper panel showed acridine orange staining of autophagosome acidic vesicles as a marker for autophagy. Lower panel showed LC3-I/II protein expression in parental cells (control) and under chronic ENZA exposure-treated vehicle control, chloroquine (CQ) or CMI. β -Actin was used as the loading control.
" to show IC50- Available in stock with overnight delivery and free shipping over $500
- Cost-effective and competitive price to save your findings
- Potent, selective and cell-permeable in inhibiting or activating target molecules
- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
- Detailed files describing potency, selectivity and applications etc.
- Supported by published data from top peer-reviewed journals
- Guaranteed high quality with NMR and HPLC validation
| Solubility | Soluble in DMSO | Storage | Desiccate at -20°C |
| Packaging | 96 well plate | Form | Powder |
| General tips | For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request | ||
A wide range of well-characterized bioactive molecules that covers various targets related to endocrinology and hormones, including androgen receptor, estrogen/progestogen receptor and RAAS etc. Facilitate your research towards the insights of diabetes, thyroid disorders and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.
1. Kaarbø M, Klokk TI, Saatcioglu F. Androgen signaling and its interactions withother signaling pathways in prostate cancer. Bioessays. 2007 Dec;29(12):1227-38.Abstract The androgen receptor (AR) is required for prostate cancer growth in all stages. This review focuses on AR function and AR-target genes and summarizes the major signaling pathways implicated in prostate cancer progression, their crosstalk with each other and with AR signaling. This complex network of interactions is providing a deeper insight into prostate carcinogenesis and may form the basis for novel diagnostic and therapeutic strategies.
品牌介绍
APExBIO（APExBIO Technology LLC）总部位于美国休斯顿，是一家自主研发生产、致力于为生命科学研究提供高性能产品和优质服务的供应商。公司现阶段涵盖丰富的产品线，主要包括：1. 10000 多种小分子抑制剂/激动剂——用于肿瘤、免疫、神经等生物医药各研究领域。2. 40 余个高通量化合物库——药物筛选最佳工具。3. 分子生物学产品——PCR、逆转录、qPCR、克隆、高通量 DNA 文库构建等试剂和试剂盒，公司对相关酶进行改造，使其稳定性、催化活性等有极大的提升。4. 体外转录——公司拥有国内独家mRNA体外转录合成平台，提供优质的修饰核苷酸、转录酶等各种合成原料，并可提供mRNA订制服务。5. Cy 染料、生物素——高纯度、种类丰富的 Cy 染料和生物素可用于蛋白检测、纯化等研究。6. 免疫学产品——各类细胞器染料及靶标信号放大的链霉亲和素系列和TSA系列。7. 试剂盒——高性能的 MTT、CCK-8、EdU 细胞增殖与毒性检测 Kit 和 Annexin V、Caspase 凋亡检测 Kit。8. 蛋白研究——蛋白提取抑制剂 cocktail、磷酸化蛋白研究新工具 phosbind。9. 组学服务——提供微生物多样性、转录组学等高通量测序服务。
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